The Prankers alum reignited her feud with the former talk show host by going on a wild rant about Oprah during her latest stand-up show! In a video obtained by TMZ on Wednesday, the comedian was on stage as an opener for Katt Williams when she WENT OFF about the “raggedy bitch.” Damn! She yelled:

“I love that Black raggedy bitch. I love that Black simple-minded motherf**ker. I love Oprah Winfrey’s Black ass and we just need to bring her back to Black.”

She then tried getting the crowd to chant along with her, asking them to yell, “f**k you, Oprah Winfrey, f**k you, Tyler Perry” and call the A-listers “c**n motherf**kers.” Jeez! While some played along, others were understandably hesitant to join in on the crude rant — and she called one of ’em out!

The performer asked an audience member named Melvin if they were a “fan” of The Color Purple star, and when the answer was “yes,” she clapped back:

“OK, well I’m not apologizing for a motherf**king thing I say.”

She went on to suggest Melvin hook up with Oprah to bring her “back to Black.” Elsewhere, Mo’Nique argued the OWN network founder and her bestie Gayle King are more than friends, saying:

“Every time you see f**king Oprah, you see f**king Gayle. Best friends is what they say. I’ve never seen best friends like that … Who is loving Oprah Winfrey and Gayle King? Each other.”

Well aware she was saying some controversial stuff, the Precious star insisted she wasn’t scared to speak her mind “out loud,” adding:

“I’m too motherf**king old to be scared of this bitch. I’m too old to be intimidated by this bitch. I’m too old to hold the motherf**king truth! You know why I f**k with Oprah Winfrey, Melvin? Cause that bitch tried to f**k with me privately. Well, I’m a public bitch. You try to fuck with me behind closed doors, bitch, open the door up. Ding dong! Imma let your motherf**king ass in.”

She really let it all out!

If you didn’t know, Mo’Nique has been feuding with Oprah (and Tyler Perry) for years, claiming they got her blackballed from the industry by allegedly spreading rumors about her — hence the dig on the 70-year-old talking about her “privately.”

Likewise, The Sovereigns of Satire alum is especially vexed that the Super Soul Sunday have “double-crossed” her by meeting her sibling, who conceded to attacking her as a youngster, on her previous television show. All the more as of late, she’s even irritated the news tycoon has begun to get jobs that were initially proposed to her. Thus, no doubt, it’s been chaotic as damnation for some time now, yet this most recent standup portion kicks it up a totally different indent! Also, it demonstrates Mo’Nique isn’t easing off this fight!!